Jergens Equine

27435 County Road 70
Gill, CO 80624


Advanced Therapies

IRAP is a moderately new therapy in horses that is used for the treatment of osteoarthritis. It has great potential for a long-term effect on battling osteoarthritis. IRAP has the ability to stop the inflammation cycle and bring comfort to your horse.

IRAP (Interleukin-1 Receptor Antagonist Protein) is a therapy for the treatment of osteoarthritis and degenerative joint disease in horses. If started early enough in the course of joint disease, IRAP can also help repair the damaged joint.  Treatment with Interleukin-1 Receptor Antagonist Protein (IRAP) utilizes progressive gene therapy to combat osteoarthritis in your horse. Interleukin-1 (IL-1) is an inflammatory compound that is secreted by many types of cells. IL-1 is an important part of the inflammatory response but in the case of your horse's joints sometimes can be detrimental. The joint fluid carries a protein called interleukin-1, which plays an important role in inflammation and accelerates the deterioration of tissues like joint cartilage. Interleukin-1 Receptor Antagonist Protein (IRAP) plays an important role by blocking IL-1 from binding to tissues and inhibits the damaging consequences of IL-1.

The procedure begins with drawing blood from the horse that will be treated with IRAP into a dedicated syringe. This syringe is specially prepared with glass beads that stimulate production of the antagonist protein and an anticoagulant. The blood is harvested, incubated and centrifuged in our lab to separate the plasma (abundant with IRAP) from the blood. IRAP treatments are individualized for each specific case.

PRP - Platelet Rich Plasma (PRP) is used to treat a variety of soft tissue (tendon and ligament) injuries. PRP is processed in house from the horse’s blood by separating the platelet rich plasma from platelet poor plasma. It is immediately injected into the concerning lesion to promote faster and stronger healing.

ProStride  - Pro-Stride reduces pain associated with arthritis and delivers naturally occurring anti-inflammatory proteins. Pro-Stride is capable of slowing cartilage degradation and improving mobility.

  • Pain relief for up to one year (A. Bertone, Am J Vet Res 2014; 75:141-151)
  • Concentrated solution of anti-inflammatory proteins
  • <20 minute blood processing,one-time visit, single injection
  • Natural, autologous drug-free therapy
  • Slows cartilage degradation
  • Ambulatory based treatment
  • Improves mobility

IRAP (Interleukin 1 receptor antagonist protein)  is a natural anti-inflammatory protein released by leukocytes at the site of injury. This protein is collected from blood by processing the leukocytes using a proprietary method. IRAP counteracts inflammation by blocking the inflammatory protein interleukin-1 within joints where if unblocked, can lead to pain and damage.  

Other IRAP devices use autologous conditioned serum, require a 24-hour incubation period, and are subsequently frozen for multiple injection aliquots.

The ACT Protein Separator used with the ACT Protein Concentrator collects white blood cells and uses a proprietary method to reprogram the cells to be anti-inflammatory, secreting IRAP. Collection and activation of macrophages suppresses joint inflammation and regenerates cartilage in early stage osteoarthritic joints.


Shockwave - Extracorporeal shock wave therapy (ESWT) is used to promote healing in horses with musculoskeletal conditions such as bone injuries or soft tissue injuries.  Extracorporeal shock waves are high-energy, focused pressure waves used for therapeutic purposes. ESWT improves the quality of healing, the speed of healing, and helps relieve pain.

Stem Cell Therapy - Stem cell therapy can be indicated in the treatment of tendon, ligament, and joint diseases in the horse. Stem Cell therapy involves obtaining a bone marrow aspirate from the horse, culturing stem cells from the aspirate and injecting the cells into the injured area. Stem cells have the capacity to differentiate into various tissue types which facilitates healing of the injured area and decreases the amount of scar tissue.